CSPT Sterile Compound Prep practice questions and answers 2026. Tap an option to test yourself — you'll see the correct answer and a plain-English explanation for every question. Free, no login.
Q11Which pressure relationship must exist in a containment segregated compounding area used for hazardous drugs?
✓ Correct answer: B. Negative pressure relative to surrounding areas
Containment segregated compounding areas for hazardous drugs must maintain negative pressure relative to surrounding areas to prevent hazardous drug vapors or particles from escaping into adjacent spaces.
Q12What is the minimum number of air changes per hour required in an ISO Class 7 buffer room?
✓ Correct answer: A. 30 air changes per hour
ISO Class 7 buffer rooms require a minimum of 30 air changes per hour to maintain proper air quality and particulate removal necessary for supporting sterile compounding operations.
Q13Which environmental monitoring method assesses the effectiveness of aseptic technique by testing the compounding personnel directly?
✓ Correct answer: D. Gloved fingertip sampling
Gloved fingertip sampling evaluates whether personnel are maintaining proper aseptic technique during compounding by testing for microbial contamination on gloved fingers after compounding activities.
Q14What type of primary engineering control uses a completely enclosed environment with glove ports for compounding?
✓ Correct answer: C. Compounding aseptic isolator
Compounding aseptic isolators and compounding aseptic containment isolators are barrier systems with glove ports that provide a completely enclosed ISO Class 5 environment, separating the operator from the compounding area.
Q15Which parameter tolerance must be continuously monitored and documented in a buffer room to ensure proper environmental control?
✓ Correct answer: B. Temperature and pressure differentials
Temperature and pressure differentials must be continuously monitored in controlled environments to ensure they remain within specified tolerances for maintaining proper air quality and preventing contamination.
Q16Why is food and drink prohibited in the buffer room and anteroom during sterile compounding operations?
✓ Correct answer: A. To prevent introduction of contaminants and microorganisms
Food and drink introduce particulates, microorganisms, and potential contaminants that can compromise the controlled environment and sterility of compounded preparations.
Q17What is the primary difference between a horizontal and vertical laminar airflow workbench?
✓ Correct answer: D. Direction of HEPA-filtered airflow
In a horizontal LAFW, HEPA-filtered air flows from the back toward the operator, while in a vertical LAFW, air flows downward from the top. Vertical flow provides better personnel protection and is preferred for hazardous compounding.
Q18How should out-of-specification environmental monitoring results be documented?
✓ Correct answer: C. Document the result, corrective actions, and retest outcomes
All out-of-specification results must be thoroughly documented with corrective actions taken, investigation findings, and retesting results to maintain compliance and ensure patient safety.
Q19Which feature distinguishes a compounding aseptic containment isolator from a standard compounding aseptic isolator?
✓ Correct answer: B. Negative pressure with externally vented exhaust
A compounding aseptic containment isolator operates under negative pressure with externally vented HEPA-filtered exhaust to provide personnel and environmental protection when handling hazardous drugs.
Q20What is the maximum humidity level recommended for maintaining proper environmental control in a buffer room?
✓ Correct answer: A. 60% relative humidity
Humidity in buffer rooms should typically be maintained at or below 60% relative humidity to prevent microbial growth, condensation, and degradation of compounded preparations while maintaining comfort and equipment function.
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